Meanings of null mutants in English

The ability to generate null mutants is essential for studying gene function.

DRAGON expression in these areas is reduced in DRG11 null mutants.

The function of this gene was studied using phoA null mutants.

In null mutants, evoked vesicle release is decreased by a factor of 10.

However, we showed previously that MAG null mutants exhibited no gross abnormality in myelination.

The previously reported mild motor phenotype of Cplx2 null mutants was accentuated upon lesion.

These abnormalities were largely absent in lesioned wild-type mice and non-lesioned Cplx2 null mutants.

Whole-body plethysmography showed irregular respiration and lower ventilatory response to hypercapnia in the null mutants.

Moreover, NRG1 processing is impaired but not abolished in BACE1 null mutants.

RL1 null mutants fail to replicate in both the PNS and CNS and are incapable of causing encephalitis.

Electron microscopy revealed that ptrn-1 null mutants have fewer MTs and abnormal MT organization in the PLM neuron.

We have developed an efficient method to create conditional lethal C. albicans null mutants by inducible, FLP-mediated gene deletion.

Loss of Muc16 protein expression suggests that Muc16 homozygous mutant mice are null mutants.

It has previously been reported that nce103 null mutants require elevated CO2 concentrations for growth in batch cultures.

We now show that all NT-3 null mutants have a similar phenotype and lose all neurons in the basal turn of the cochlea.

Phenotypic characterization of six ASG- null mutants demonstrated that these genes are dispensable for in vitro growth but play defined roles in host-pathogen interactions.