Meanings of often refractory in English

G. argillacea infections in CGD are often refractory and severe with a high fatality rate.

Host protein recruitment to pathogens is often refractory to accurate automated assessment due to its heterogeneous nature.

Female voiding dysfunction such as urge-frequency syndrome, urge incontinence and unobstructive urinary retention are often refractory to conservative management.

"Have you been often refractory since you came here?"