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The first federal trial, involving claims by two Ohio counties, begins in October.
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The drug seizures are concentrated in a handful of Ohio counties, many of them rural.
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The trial will pit two Ohio counties against five companies the local governments say helped fuel a nationwide crisis.
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The verdict came as two Ohio counties prepare for a scheduled October trial before a federal judge in Cleveland.
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SafeChain uses blockchain technology to prevent real-estate wire fraud and digitises property deed and title transfers for numerous Ohio counties.
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The Ohio counties scheduled for the bellwether trial have conducted extensive discovery and have reached several settlements, the 6th Circuit said.
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Earlier this month, the company agreed to pay $20.4 million to settle claims by two Ohio counties, avoiding a federal opioid trial.
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While these purchases were being made, agents were dispatched into several Ohio counties, and more than 20,000 acres of well tested coal lands were secured.