1
Binding to dsRNA activates the enzyme by inducing an open conformation and enhancing dimerization.
2
The crystal structure docks well into the open conformation.
3
This led to the interpretation that the active site is trapped in an open conformation.
4
Larger population studies are warranted to assess whether the open conformation tissue-transglutaminase assay may be superior to the conventional assay.
5
MscS was trapped in its open conformation after the transbilayer pressure profile was modified through the asymmetric incorporation of lysophospholipids.
6
These studies reveal that TAF4b incorporation into TFIID induces an open conformation at the lobe involved in TFIIA and putative activator interactions.
7
This domain of approximately 900 kb is in an open conformation over its length and is generally susceptible to all Shh enhancers.
8
Electron microscopy of two of these antibodies bound with near-native gp140 trimers showed that they recognized an open conformation of the Env trimer.
9
Finally, a long-term follow-up study in 1 iTTP patient showed that the open conformation precedes a substantial drop in ADAMTS13 activity.
10
The simulation of the open conformation gave a probe mobility that was 35-40° greater than that observed experimentally for the A·MV·SLADP state.
11
When the native (2.4 M ammonium sulfate) crystals are transferred to a sulfate-free mother liquor, the flexible loop of subunit-2 adopts the open conformation.
12
The asymmetric units of both crystal forms contain two protomers A and B with closed and open conformations, respectively.
13
The transition between the closed and open conformations of the Sec61 complex permits nascent protein insertion into the translocation channel.
14
This regulation appears tightly linked with scavenger receptor BI dependency, suggesting a role of this receptor in transitions from closed to open conformations during entry.
15
ESCRT-0 typifies a class of biomolecular assemblies that combine structured and unstructured elements, and have dynamic and open conformations to ensure versatility in target recognition.
