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1
In this review we will focus primarily on the insulin-producing
pancreatic
beta
-
cell
.
2
Several isoforms of the leptin receptor are expressed in
pancreatic
beta
cells.
3
These findings may have implication on new mechanism of glucotoxicity-mediated
pancreatic
beta
-
cell
dysfunction.
4
We have investigated the functional consequences of ablating NCAM on
pancreatic
beta
-
cell
function.
5
Diabetes is characterized by the loss, or gradual dysfunction, of insulin-producing
pancreatic
beta
-
cells
.
6
Prolonged exposure to elevated levels of fatty acids adversely affects
pancreatic
beta
-
cell
function.
7
During pregnancy, the
pancreatic
beta
-
cells
display a highly reproducible physiological proliferation.
8
In
pancreatic
beta
cells, this would lead to less insulin secretion and thereby diabetes.
9
The
pancreatic
beta
cell is the major source of circulating insulin in adult mammals.
10
Glucocorticoid doses, insulin sensitivity and
pancreatic
beta
cell function were compared among these groups.
11
In conclusion, independently of glucose, insulin can mediate mitogenesis in fetal
pancreatic
beta
-
cell
lines.
12
Long-chain fatty acids amplify insulin secretion from the
pancreatic
beta
-
cell
.
13
Type 1 diabetes is an autoimmune disorder characterized by chronic inflammation and
pancreatic
beta
-
cell
loss.
14
In
pancreatic
beta
-
cells
especially, mitochondrial dysfunction impairs insulin secretion and the eventual apoptosis of beta-cells.
15
Ba currents flowing through single Ca-channels were recorded from cell-attached patches on rat
pancreatic
beta
-
cells
.
16
These results indicate that PPARalpha improves the adaptative response of the
pancreatic
beta
-
cell
to pathological conditions.
pancreatic
beta
pancreatic