Indomethacin is unique in its use in the diagnosis and treatment of hemicrania continua and paroxysmal hemicrania.

By definition, it is completely efficacious in the treatment of the primary headache disorders paroxysmal hemicrania and hemicrania continua.

The differences in profile of effect of indomethacin may be fundamental to its ability to treat paroxysmal hemicrania and hemicrania continua.