1 Conclusion: The host cell response to Sindbis is triggered through PKR activation.
2 The action of PKR involves RNA-dependent autophosphorylation leading to inhibition of translation.
3 The kinase PKR is a central component of the interferon antiviral pathway.
4 Upon binding double-stranded RNA, PKR undergoes autophosphorylation reactions that activate the kinase.
5 These results suggested the involvement of PKR in influenza virus-induced cell death.
6 Conclusions: Our findings suggest that PKR protein expression may controlled by transcription level.
7 The major activators of PKR have been proposed to be long double-stranded RNAs.
8 Some highly structured viral RNAs do not activate and function as PKR inhibitors.
9 PKR contains an N-terminal dsRNA-binding domain and a C-terminal kinase domain.
10 Thus, PKR belongs to the growing family of proteins that contain intrinsically unstructured regions.
11 Currency dealers said the blast had not affected trade in the rupee PKR = .
12 Cells use the interferon-induced, double-stranded-RNA-dependent protein kinase PKR as a defense against virus infections.
13 PKR is activated to undergo autophosphorylation upon binding to RNAs that contain duplex regions.
14 The Pakistani Government would have financed the project to the tune of 10 million PKR .
15 PKR activation results in translation inhibition through eIF2alpha phosphorylation and initiation of the stress response.
16 Protein kinase R ( PKR ) is an essential component of the innate immune response.
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