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As a polygenicdisorder, genetic studies have only started to shed light on its complex etiology.
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The data provide strong evidence for the model of Crohn's disease and ulcerative colitis as related polygenicdisorders.
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Systematic screening of the entire human genome now provides a strategy for the identification of susceptibility genes in complex polygenicdisorders.
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Neuropsychiatric disorders are highly heritable polygenicdisorders arising from the complex interplay of highly penetrant rare variants and common variants of small effect.