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As part of our ongoing studies into the mechanisms and control of polyketide biosynthesis, we report the second structure of a polyketidesynthase ACP.
2
Although many carrier protein three-dimensional structures have been determined, to date there is no model available for a fungal type I polyketidesynthase ACP.
3
Our results indicate that PteF activates the transcription from two promoters of polyketidesynthase genes directly, and indirectly of other genes of the cluster.
4
Further, the native gene responsible for the production of macrolactin, the gene encoding polyketidesynthase was reduced in copy number after the application of macrolactin.