Meanings of pre-mrna splicing in English

The protein factor U2AF is an essential component required for pre-mRNA splicing.

Adenosine-to-inosine RNA editing and pre-mRNA splicing largely occur cotranscriptionally and influence each other.

Aberrant alternative pre-mRNA splicing (AS) events have been associated with several disorders.

Defects at the level of the pre-mRNA splicing process represent a major cause of human disease.

Nuclear pre-mRNA splicing has a fundamentally similar two-step mechanism to that employed by group II self-splicing introns.

Exonic variants can alter pre-mRNA splicing either by changing splice sites or by modifying splicing regulatory elements.

These transition steps were investigated using microarrays, both at the level of gene expression and alternative pre-mRNA splicing.

To catalyze pre-mRNA splicing, U6 small nuclear RNA positions two metals that interact directly with the scissile phosphates.

It has been shown to play an important role in cell-cell and cell-matrix interactions and in pre-mRNA splicing.

We further found that the pre-mRNA splicing efficiency of these genes were impaired when Cdc5L was knocked down.

We constructed minigenes to study the effects of PRPF31 mutations on the pre-mRNA splicing of these photoreceptor specific genes.

Intron removal through pre-mRNA splicing is tightly linked to transcription by RNA polymerase II as it translocates along each gene.

Pre-mRNA splicing is regulated by transcription elongation rates and vice versa, yet the rates of RNA processing reactions remain largely elusive.

This review focuses on recent progress in identifying adRP mutations in genes encoding pre-mRNA splicing factors and the potential underlying molecular mechanisms.

The identification of mutations in a pre-mRNA splicing gene implicates defects in the splicing process as a novel mechanism of photoreceptor degeneration.

Furthermore these data demonstrate that recognition of an RNA as a substrate for a pre-mRNA splicing reaction is, at least qualitatively, only intron dependent.