Precancerous conditions in which abnormalities in the peripheral blood or bone marrow represent the early manifestations of acute leukemia, but in which the changes are not enough to permit a diagnosis of acute leukemia.
Ten patients with preleukemia and life-threatening pancytopenia were treated with marrow transplantation.
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Specimens were obtained from patients with preleukemia and associated antigen weakening, and from individuals with normal antigen values.
3
This experience also emphasizes the importance of performing chromosome studies before transplantation for pancytopenic states in order to identify cases of preleukemia.