Background: Patients with high-risk primary breast cancer remain at high risk for relapse.

In contrast, the incidence rates of second primary breast cancer are largely undocumented.

Methods: FDG-PET was performed before surgery in 275 women with primary breast cancer.

Methods: BM aspirates from 137 primary breast cancer patients were included into the study.

Average age at diagnosis of first primary breast cancer had increased significantly since 1970.

COX-2 also correlated with VEGF expression in primary breast cancer.

Background: Tamoxifen treatment greatly reduces a woman's risk of developing a second primary breast cancer.

We conclude that mitochondrial response to metformin in primary breast cancer may define anti-tumor effect.

During the period under study, 205 women had a recurrence or new primary breast cancer.

Alterations of p53 are one of the most common abnormalities detected in primary breast cancer.

Fresh tumor samples were collected during surgery from 344 patients diagnosed with primary breast cancer.

Risk of second primary breast cancer after various types of nonbreast cancer was also computed.

In the current study, HLA-G expression in 58 primary breast cancer lesions was analyzed with immunohistochemistry.

Conclusions: Having a hormone receptor negative first primary breast cancer is associated with increased risk of CBC.

Bone scintigraphy of a 40-yr-old patient suffering from primary breast cancer suggested the possibility of diffuse metastases.

Discrepancies have been reported between HER2 status in primary breast cancer and micrometastatic cells in bone marrow.