1
DC are professional APC that instruct T cells during the inflammatory course of EAE.
2
Dendritic cells are professional APCs that play a central role in the initiation of immune responses.
3
B7S1 is expressed on professional APC and widely distributed in nonlymphoid tissues.
4
Moreover, these studies show that different subsets of professional APC can selectively modulate DNA vaccine-elicited T lymphocyte responses.
5
We also discuss the implications of these findings on the role of professional APCs in the initiation of CTL responses.
6
These data demonstrate the critical importance of locally recruited professional APC in determining the magnitude and nature of immune responses elicited by plasmid DNA vaccines.
7
The level of the induced E7-specific CD8(+) T cell response proved to be dependent on the interactions of these Th cells with professional APC.