Both classic and milder phenotypes develop progressive neurodegeneration in early adulthood.

The ceroid accumulation primarily affects the brain, leading to neuronal loss and progressive neurodegeneration.

All together these results suggest that in AD an inefficient IgG 3 humoral immune response, failing to block viral replication, contributes to progressive neurodegeneration.

In experimental SCI models, we and others have reported that such changes reflect sustained microglia activation in the brain that is associated with progressive neurodegeneration.