The current studies identify a new role for Akt in CNS myelination.
2
Conclusion: The Akt-Caspase 3 signal pathway may be involved in these processes.
3
We compared this effect by Western Blot analysis of Akt protein expression.
4
Moreover, the CG treatment down-regulated the phosphorylation levels of Akt and GSK3β.
5
Methods: Akt-2 expression was analyzed by western-blotting and Q-PCR in cell lines.
1
This makes inhibition of PKB signaling pathway a promising strategy for cancer therapy.
2
Experiments were performed in MER-Akt cells to investigate the role of PKB in controlling mTOR.
3
PKB's support will add weight to his candidacy.
4
NU says it communicates regularly with PKB but has no intention of intervening in policy affairs.
5
These results demonstrate that PKB activity in early G1 phase is required to prevent the induction of apoptosis.
1
Activation of Akt, or proteinkinaseB, is frequently observed in human cancers.
2
Both agents lowered proteinkinaseB activity, but this was not mediated by inhibiting phosphoinositide 3-kinase.
3
We found a high level of proteinkinaseB (AKT) phosphorylation after 6 h of cold exposure.
4
The Akt ( proteinkinaseB) kinase is a key player in transduction of antiapoptotic and proliferative signals in T cells.
5
A lower level of phosphorylated proteinkinaseB was observed in PFKFB3-knockdown endothelial cells, which was accompanied by a decrease in intracellular lactate.
1
All of these changes involve long-term activation of the proteinkinaseAkt.
2
The host cells demonstrated increased phosphorylation of major survivor proteinkinaseAKT correlating with reduced toxicity of the mutant in comparison with Sterne.