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The N-terminal domain is conserved in all members of the IGF-binding proteinsuperfamily.
2
Tubulins are a universally conserved proteinsuperfamily that carry out diverse biological roles by assembling filaments with very different architectures.
3
Genomic enzymology is the study of protein structure-function in light of genetic context and evolution of proteinsuperfamilies.
4
We present an update of ligand binding in large proteinsuperfamilies and identify those ligands most frequently utilized by nature.
5
Efflux pump gene proteinsuperfamilies have been characterized by genome analysis of drug resistant strains and through in vitro transcriptional studies.