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1 PTHrP is produced in a wide variety of different cells, including cardiomyocytes.
2 After surgical resection of these tumors, her plasma PTHrP level was normalized.
3 PTH and PTHrP both act in the regulation of fetal mineral metabolism.
4 The potential for cell-specific secretory pathway use by PTHrP has not been explored.
5 Thus, the secretion of PTHrP is unique in that it appears to be cell-specific.
6 These data provide new insights into the molecular mechanisms involved in PTHrP regulation of cementogenesis.
7 A number of biological activities have been ascribed to actions of other domains within PTHrP .
8 Competition binding curves were performed during differentiation using 125I - PTHrP .
9 Furthermore, the effects of PTH and PTHrP on apoptosis were dramatically dependent on cell status.
10 Inactivation of Pthrp in mice results in short-limbed dwarfism because of premature differentiation of chondrocyte.
11 Plasma i - PTHrP was significantly correlated with left ventricular ejection fraction and end-diastolic and end-systolic dimensions.
12 PTHrP also stimulates transport of calcium across the placenta.
13 The decline in osteoclast number was partly restored by the addition of PTHrP to the culture.
14 Moreover, treatment restored normal responsiveness to calcitriol suppression and maintained normal PTHrP responsiveness of enzyme activity.
15 These results suggest that PTHrP expression can be used as a prognostic factor for mucoepidermoid carcinoma.
16 These and other findings thus indicate that PTHrP and its receptor are essential for chondrocyte differentiation.
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