Our results have identified 414 protein targets for modification by reactive aldehydes in ALD.

Early B cells from these mice exhibit excess reactive oxygen species and reduced metabolism of reactive aldehydes.

Cardiac ischemia and reperfusion promote oxidative stress, leading to the accumulation of reactive aldehydes that cause cardiac damage.

Mitochondrial aldehyde dehydrogenase 2 is emerging as a key cardioprotective enzyme for its central role in the detoxification of reactive aldehydes.

The production of reactive aldehydes such as 4-hydroxynonenal (4-HNE) is proposed to be an important factor in the etiology of alcoholic liver disease.