These results provide a potential mechanism of how CHBP protects against renal IRI.

Our results suggest a promising role for HUCB-MSCs in the treatment of renal IRI.

To examine whether these observations were relevant to renal IRI, we administered Slit2 to mice before bilateral clamping of the renal pedicles.

Collectively, these results suggest that Slit2 may hold promise as a strategy to combat renal IRI without compromising the protective innate immune response.

Here we investigated the role of the signal transducer and activator of transcription 1 (STAT1) in inflammatory responses following renal IRI.