Meanings of second substitution in English

It was, however, Pearson's second substitution which brought his side back into the game.

Their luck deteriorated before half-time, as injury to Targett compelled them to make a second substitution.

The second substitution removes the quotation marks.

A second substitution made during half-time saw Gelson Dala, who scored three of the nine goals that took Angola to the finals, replacing Wilson Eduardo.

The second substitution at position 87 in GyrA (replacing the amino acid Asp) appeared helpful for epidemiological studies to track the origin of contamination.