Meanings of senescent phenotype in English

These cells gradually adopted a senescent phenotype with impairment of self-renewal properties.

In order to progress, tumor cells thus need to first overcome the senescent phenotype.

Morphological imaging studies showed a flatter and spread-out nucleus in the senescent HBMECs, both characteristic features of a senescent phenotype.

We found that lapatinib treatment resulted in phenotypic alterations consistent with a senescent phenotype and strong SA-β-gal activity in HER2-positive cell lines.

Morphological change is one of the cardinal features of the senescent phenotype; for example, senescent human diploid cells have a flat large shape.

Our studies show that exposure to Aβ1-42 oligomers may impair vascular functions by altering VEGFR-1 expression and causing ECs to enter a senescent phenotype.

Senescent cells display altered metabolic signatures that can either be causal for aspects the senescent phenotype, or act as biomarkers for senescence.