The risk of in-hospital death was higher among patients with more severe AKI.

Presence of 4 alleles of HLA-DRB in severe AKI patients seems associated with a lower need of RRT.

To study this, we conducted a 12-center open-label pilot trial of critically ill adults with volume replete severe AKI.

We sought to develop and validate a risk model for predicting severe AKI within 72 hours after intensive care unit admission.

In these patients, a decrease in SBP relative to pre-morbid value is a significant independent predictor of the development of severe AKI.

Both urinary chitinase 3-like protein 1 and -3 were only detected in septic mice with severe AKI.

Patients who suffer severe AKI have a higher risk of developing interstitial fibrosis, chronic kidney disease, and end-stage renal disease later in life.

The ACT model had moderate positive predictive values (0.50-0.95) and high negative predictive values (0.94-0.95) for severe AKI in all three cohorts.