Meanings of severe defect in English

TRAF6-deficient mice showed a severe defect in the Treg development in thymus.

Falsifying application documents would also qualify as a " severe defect", the report said.

These mutant mice exhibit a severe defect in JNK activation caused by feeding of a high-fat diet.

Infantile osteopetrosis is a lethal disorder resulting from a severe defect in the ability of osteoclasts to resorb bone.

Two chromosomal TnphoA insertion mutations of the strain were isolated that showed a severe defect in the amount of EtxB produced.

Altogether, our data suggest that the severe defect of thymic Treg is at least partially due to MG TECs that overproduce TSLP.

Flow cytometry analysis of mitochondria respiratory function in the thyroid tumor cell lines revealed a severe defect in mitochondrial complex I activity.

Neural tube defects are one of the commonest congenital malformations of the central nervous system, with anencephaly being the most severe defect.

These deficiencies lead to a severe defect in respiration in the transmitochondrial cybrids, consistent with the profound mitochondrial disorder originally associated with this mutation.

In addition to marked alterations in epidermal development, the transgenic mice had a severe defect in lactation during pregnancy resulting in 100% pup mortality.

Under slow-growth conditions, the DeltadipM mutant displays severe defects in cell division and FtsZ constriction.

Analysis of knockout embryos revealed severe defects in the reorganization of the yolk sac vascular plexus.

Extended GAPM1a depletion leads to severe defects in division, reminiscent of the effect of disrupting other alveolar proteins.

Upon conditional deletion of GATA-3, mice exhibited severe defects in mammary development due to failure in TEB formation during puberty.

These findings suggest that many without severe defects have similar challenges and may likewise benefit from such an evaluation, he said.

Conclusions: The diverse and severe defects observed emphasize the central role of the wolffian duct in providing progenitors and signals for urogenital development.