Rotaviruses are the most common infectious agents causing severe diarrheal diseases in young children globally.

Rotavirus (RV) was a major cause of the severe diarrheal disease in young children and young animals.

The apicomplexan parasite Cryptosporidium is a leading global cause of severe diarrheal disease and an important contributor to early-childhood mortality.

Vibrio cholerae, the causative agent of the severe diarrheal disease cholera, thrives in both marine environments and the human host.