1
In humans short telomeres have been linked to morbidity and mortality.
2
Cases of chromosome fusion involving extremely short telomeres have been reported at advanced stage.
3
Moreover, the two cases of SC in the prospective HL patients had short telomeres and CCR initially.
4
Telomeric Flow-FISH and quantitative telomeric FISH on mitotic preparations showed that malignant cells had relatively short telomeres.
5
We surveyed a series of mutants with DNA repair defects, and found many of them to have short telomeres.
6
However, not all people under stress have distinctly short telomeres, and we examined whether exercise can serve a stress-buffering function.
7
Mechanistically, short telomeres and compromised DNA damage response in cells of Ataxia Telangiectasia patients may be linked with frequent chromothripsis.
8
By culling cells with dysfunctional telomeres, p53 plays a critical role in protecting tissues against the effects of critically short telomeres.
9
It appears that telomerase inhibition in cells with short telomeres lead to chromosomal damage, which in turn trigger apoptotic cell death.
10
An unanswered question is whether inherited short telomeres or therapy-related telomere shortening is a biomarker of the development of second malignant neoplasms.
11
Previous studies indicated that short telomeres are associated with increased risk for human bladder, head and neck, lung, and renal cell cancer.
12
Telomeres, the repetitive DNA-protein structures at chromosome ends, influence cellular replicative capacity in that critically short telomeres can induce cell senescence or apoptosis.
13
Short telomeres are almost universally associated with malignant cancer progression.
14
Short telomeres and increased DNA damage, senescence, and infiltrating leukocytes were observed in biopsies located less than 10 cm from HGD or cancer.
