Previous studies showed that both signalization and adding RLCs reduced angle crashes but increased rear-end crashes.

Thus, the objective of this study is to investigate trends of CMFs for the signalization and adding RLCs over time.

In particular, the ARMA model predicted a significant safety effect of the signalization on reducing angle and left-turn crashes in the long term.

The Rail & Road division is specialized in signalization and track-laying works, railway works, transport of energy high and low voltage lines, among others.

However many aspects of TSH receptor signalization remain to be explored, for example its persistent activity after internalization, and their clinical implications to be determined.