Results: No genetic marker was significantly associated with the primary endpoint, clinically significant exacerbation rate.

Conclusion: Hookworm infection did not cause clinically significant exacerbation of airway responsiveness and was well tolerated.

Three major classes of episodic outcome are defined: relapse or significant exacerbation, nonrelapse, and stable, severe persisting symptoms.

Spontaneously hypertensive rats (SHR) of the Okamoto strain exhibit a significant exacerbation in severity of hypertension when fed diets high in NaCl.

The rates of severe side effects were comparable to other patient populations and no patient developed significant exacerbations of GVHD.