L.A.'s no place for the weak-minded and being Punk carries a significant responsibility.

It becomes possible to influence how people think about a given question and with that comes significant responsibility.

The drinks industry (both publicans and producers) has to take a significant responsibility for this state of affairs.

The reports also singled out Barry Zubrow, the bank's former chief risk officer, who was also singled out for " significant responsibility for failures."

In many cases, trustees are lay people who have significant responsibilities placed on them.

He had practised great self-repression; he had accepted his future life suddenly, but with all its significant responsibilities.