The sinogram bootstrap analysis revealed that DRAMA reconstruction resulted in less statistical noise, especially in a low-activity region compared to FBP.

To estimate the statistical variance of reconstructed images on a pixel-by-pixel basis, a sinogram bootstrap method was applied using list-mode PET data.

The first step involves a new form of the rebinning operation in which multiple sinograms are incremented for each oblique coincidence line (multi-slice rebinning).

Independent Poisson noise is introduced to the high-count sinograms to generate 200 pairs of lesion-present and lesion-absent datasets, each mimicking a 5-min scan.