These genes have tissue-specific patterns of expression that may predict specialized roles.

Gene silencing revealed specialized roles of insulin signaling cascades to metabolic endpoints.

A larger organism might have different vendeks playing specialized roles.

Autophagy is a fundamental biologic process that fulfills general and specialized roles in cytoplasmic homeostasis.

The other BAFF receptors showed a much more restricted expression pattern, suggestive of specialized roles.

Collectively, our results reveal a new family of DUBs that may have specialized roles in regulating proteostasis.

This suggests specialized roles for these cells in host defense and in the development of cerebral interferonopathy.