Meanings of specific ablation in English

This study aimed to establish a lesioning method with a complete and specific ablation.

We generated conditional and inducible mouse lines with muscle- specific ablation of the core clock gene Bmal1.

Here, we describe the methods of establishing and analyzing nervous system- specific ablation of FOXO isoforms in mice.

Here, we show that epidermis- specific ablation of Nir impairs epidermal stratification and barrier function, resulting in perinatal lethality.

Here we report that mice with specific ablation of Jnk1 in hepatocytes exhibit glucose intolerance, insulin resistance, and hepatic steatosis.

B cell- specific ablation of TBK1 in mice resulted in uncontrolled production of IgA and the development of nephropathy-like disease signs.

Here we show that squamous cell carcinomas generated by the specific ablation of Trp53 gene in mouse epidermis are highly metastatic.

Consistently, cell- specific ablation of dopamine-excitable cells in dorsal, but not ventral, striatum inhibited sugar's ability to drive the ingestion of unpalatable solutions.

An opposite effect was observed in ECs isolated from animals with endothelial- specific ablation of Klf2, Klf4 or both.

We found that specific ablation of the proapoptotic function of cytochrome c, a key regulator of mitochondria-mediated apoptosis, enhanced autophagy following chemotherapeutic treatment.

Genetic activation of this pathway improved postprandial glucose disposal in mice, whereas its muscle- specific ablation impaired insulin action and led to postprandial glucose intolerance.

Surprisingly, T cell- but not Treg cell- specific ablation of TGF-β1 was sufficient to augment T cell cytotoxic activity and blocked tumor growth and metastases.

Tissue- specific ablation of different dynamin isoforms bypasses the early lethality of conventional knock-outs and allows us to examine CH development in a native brain circuit.

Introduction: Complete and specific ablation of a single dopaminergic (DA) pathway is a critical step to distinguish the roles of DA pathways in vivo.

BMP4 limits mossy fiber growth in vitro and Purkinje cell- specific ablation of BMP4 in mice results in exuberant mossy fiber-Purkinje cell interactions.

T cell- specific ablation of both STIM1 and STIM2 resulted in a notable lymphoproliferative phenotype and a selective decrease in regulatory T cell numbers.