Interestingly, Pten liver- specific deletion causes enhanced liver insulin action with improved systemic glucose tolerance.

Myeloid- specific deletion of SIRT1 stimulates obesity-induced inflammation and increases the risk of hepatic fibrosis.

Hepatocyte- specific deletion of HNF4a resulted in increased hepatocyte proliferation.

We demonstrated that neuron subset- specific deletion of PTEN in mice led to deficits in motor coordination.

The organ- specific deletion of SIRT1 induces local inflammation and insulin resistance in dietary and genetic obesity.

In adult mice, acute, muscle- specific deletion of Opa1 induces a precocious senescence phenotype and premature death.

Keratinocyte- specific deletion of ADAM17 in mice impairs terminal differentiation of keratinocytes leading to severe epidermal barrier defects.

PC- specific deletion of AMPKa or PGC1a causes defective PC maturation, which could not be rescued by metformin.

Here, we generate a transgenic mouse that enables cell- specific deletion of the H-2Kb MHC class I molecule.

However, loss of AIS proteins by the neuron- specific deletion of the master AIS scaffold AnkyrinG disrupted microglia-AIS interactions.

Death in utero caused by ubiquitous ERp57 deletion was prevented by specific deletion in the B cell compartment.

Monocyte- specific deletion of Ddah2 results in a similar pattern of increased severity to that seen in globally deficient animals.

Pancreas- specific deletion of Adrb2 results in glucose intolerance and impaired insulin secretion in mice, and unexpectedly, specifically in females.

Liver- specific deletion of Notum did not modify liver zonation, but Notum deletion had a long-term effect on mouse physiology.

The endothelial cell- specific deletion of Gas in mice causes early embryonic lethality with massive hemorrhage and a disorganized vasculature.

Endothelial- specific deletion of Sox2 decreased expression of stem cell markers and aortic calcification in matrix γ-carboxyglutamic acid protein-deficient mice.