Meanings of specific inactivation in English

We confirmed experimentally that forebrain- specific inactivation of Cfl1 decreased anxiety in knockout mice.

Here we describe the effects of cartilage- specific inactivation of the Rac1 gene in mice.

Furthermore, tissue- specific inactivation of Fgf18 in the early palatal mesenchyme did not cause cleft palate.

Liver- specific inactivation of Blnc1 abrogates high-fat diet-induced hepatic steatosis and insulin resistance and protects mice from diet-induced nonalcoholic steatohepatitis.

We show that cardiomyocyte- specific inactivation of tumor suppressor PTEN results in hypertrophy, and unexpectedly, a dramatic decrease in cardiac contractility.

Hepatocyte- specific inactivation of hnRNPU disrupted liver chromatin accessibility, activated molecular signature of NASH, and sensitized mice to diet-induced NASH pathogenesis.

We have discovered an unanticipated role for MEF2C in the neural crest, where tissue- specific inactivation results in neonatal lethality due to severe craniofacial defects.

Specific inactivation of pdx1 in adult beta cells revealed that this gene is required for maintenance of mature beta cell function.