Meanings of substantial obstacles in English

The high-flying executive is also trying to run Twitter, another company with substantial obstacles to growing profits.

Females were smaller, but both were quick and agile, able to climb steep slopes and leap over substantial obstacles.

While gene therapy has the potential to achieve this, substantial obstacles must be overcome before clinical application can be considered.

There is sufficient evidence that Louisiana's measure "would place substantial obstacles in the path of women seeking an abortion in Louisiana," Breyer added.