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1 The main feature of these cells is their potent immune suppressive activity .
2 Many effectors show defence- suppressive activity that is important for pathogen virulence.
3 The suppressive activity was measured by an assay of inhibition of lymphocyte activation.
4 Moreover, the mechanism of FOXP3-mediated tumor- suppressive activity remains largely unknown.
5 However, they have potent suppressive activity and distinct gene expression profiles and biochemical characteristics.
6 Importantly, inhibition of Stat3 abolished their suppressive activity almost completely.
7 IL-17A also promoted the suppressive activity of MDSC to reinforce suppression of tumoral immunity.
8 The suppressive activity of Treg cells in ITP patients was also found to be impaired.
9 We conclude that H4R stimulation enriches for a regulatory T cell with potent suppressive activity for proliferation.
10 Their immune- suppressive activity can inhibit inflammation-associated cancers.
11 Thus, it is likely that not all Foxp3+ T cells in SLE have protective suppressive activity .
12 However, the oncogenic role of STAT3 in cancers has been challenged by several reports that suggest a tumor- suppressive activity .
13 The tumor- suppressive activity of FOXP3 has been observed in tumor initiation, but the underlying mechanism still remains largely unknown.
14 The tumor- suppressive activity of FOXP3 has been observed in tumor initiation, but its role during tumor progression remains controversial.
15 Analysis of various nuclear and cytoplasmic PML isoforms showed that the PML growth suppressive activity correlates with its nuclear localization.
16 Notably, the suppressive activity of these Treg cells required cell-cell contact and was not mediated through soluble IL-10 or TGF-beta.
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