Meanings of suppressive role in English

Recently, it has become apparent that KIF4 plays a crucial suppressive role in tumorigenesis.

This study examined FUS1 expression and its possible tumor- suppressive role in bone and soft tissue sarcomas.

To properly assess the role of rapamycin-induced autophagy, the immune suppressive role of rapamycin should be negated.

These findings suggest that ACSL4 plays a tumor- suppressive role and could be a potential therapeutic target in GC.

Promoter methylation is negatively correlated with the gene expression level, indicating its suppressive role in regulating gene transcription.

With regard to its role in carcinogenesis, there is conflicting evidence as to whether WNT5A has a tumour-promoting or tumour- suppressive role.

This study was undertaken to examine the suppressive role of TLR-9 in the development of severe lupus in a mouse model.

Accordingly, CTLA-4 plays an important suppressive role in T-cell priming and protective immunity in a prime-challenge model of acute bacterial infection.

These data unravel a tumor suppressive role of NLK and support the feasibility of combining oncogenomics with in vivo RNAi screen.

To further validate the results in vivo, we evaluated the tumor suppressive role of WWOX in mouse model of gallbladder cancer.

Recently, studies have illustrated the essential tumor suppressive role of ARID1A in several cancer types, but its role in SCCs remains unclear.

Together, these findings established that JNK signaling is required for normal mammary gland development and that it has a suppressive role in mammary tumorigenesis.

Collectively, our results indicate that miR-135a targets ASPH to inhibit EC cell proliferation and migration, suggesting a tumor suppressive role of miR-135a in EC.

The results demonstrated that miR-874 may serve tumor suppressive roles in PDAC by directly targeting PAX6.