Meanings of target deletion in English

Targeted deletion of HIF-1alpha in ADAS substantially inhibited the chondrogenic pathway specifically.

Conclusions: Targeted deletion of TIMP-2 results in attenuation of aneurysm development.

Targeted deletion of VGLUT1 in mice causes lethality in the third postnatal week.

Similar findings were observed in brain tissue and fibroblasts from mice with targeted deletion of Pur-alpha.

Targeted deletion of BK channel in mice resulted in an osteoclast-autonomous osteopenia, becoming apparent in juvenile females.

Animal modeling has shown that mice with targeted deletions in the Ink4a-Arf gene do not develop spontaneous gliomas.

We generated a targeted deletion of the cmpy locus and find that loss-of-function mutants exhibit excessive NMJ growth.

Targeted deletion of Wwox in mice causes increased spontaneous tumor incidence, confirming that WWOX is a bona fide tumor suppressor gene.

We have evaluated the roles of NO and CO in intestinal neurotransmission using mice with targeted deletions of nNOS or HO-2.

Methods: Mice with targeted deletion of the MCP-1 gene and wild type controls were administered a single intragastric dose of carbon tetrachloride.

Targeted deletion of the Aspergillus nidulans kinase gene indicates that this kinase is involved in germination of conidial spores and polarized growth.

Targeted deletion of nucleostemin in the mouse results in developmental arrest at the implantation stage, indicating that nucleostemin is crucial for early embryogenesis.

Targeted deletion of PTH2, generated mutants that were completely non-pathogenic, lacked CAT activity and were unable to utilize a range of lipid substrates.

Targeted deletion of the apolipoprotein E gene results in severe hypercholesterolemia and spontaneous atherosclerosis, with lesions containing large numbers of T cells and macrophages.

Mice with targeted deletion of PLSCR1 display perinatal granulocytopenia due to defective response of hematopoietic precursors to granulocyte colony-stimulating factor and stem cell factor.

We have created mice with a targeted deletion of IP6K1 in which production of inositol pyrophosphates is markedly diminished.