Meanings of termination codon in English

The remainder of the sequence corresponded to the 3'-region of the mRNA downstream from the termination codon.

Furthermore, the most C-terminally located premature termination codon mutation fails to rescue the progenitor cell proliferation defect in hippocampal slice cultures from Bcl11b-deficient mice.

RNA analysis revealed that an alternative splice site within exon 1 was used leading to a premature termination codon within exon 2.

Affected animals carry a mutation that predicts a premature termination codon in exon 8 and a peptide that is 5% the size of normal dystrophin.

Due to premature termination codons, none encodes functional protein.

These cytoplasmic introns were found to be highly conserved and introduced premature termination codons into coding regions.

The mutation was associated with two shortened transcripts, both with shifted reading frames resulting in premature- termination codons.

The presence of termination codons in all three reading frames suggests that the common region probably does not contain coding sequences.

We found that one-third of the alternative transcripts examined contain premature termination codons, and most persist even after rigorous filtering by multiple methods.

Finally, our analyses suggested that premature termination codons in selenoprotein genes trigger nonsense-mediated decay, but do this inefficiently when UGA codon is gained.

The majority of these mutations result in premature termination codons that would be predicted to trigger nonsense-mediated decay (NMD) of mutant mRNA and cause haploinsufficiency.

A total of 11 disease-causing WNT1 variants (7 missense mutations, 4 mutations leading to premature termination codons) were identified, of which 9 were novel.