Meanings of toxic gain in English

RBP aggregation results in both toxic gain and loss of normal function.

The molecular mechanism underlying the toxic gain-of-function of mutant hSOD1s remains uncertain.

These findings suggest that FSHD arises through a toxic gain of function attributable to the stabilized distal DUX4 transcript.

These results suggest that mutant TDP-43 is mislocalized to the cytoplasm, where it exhibits a toxic gain-of-function and induces cell death.

Our findings support that SIMPLE mutation disrupts myelin homeostasis and causes peripheral neuropathy via a combination of toxic gain-of-function and dominant-negative mechanisms.

Thus, nuclear retention of mutant ataxin-1 may be an important toxic gain of function in SCA1 disease.

It is currently unclear whether transfer of tau between neurons is a toxic gain-of-function process in dementia or reflects a constitutive biological process.