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X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disorder resulting in cerebral demyelination, axonal dysfunction in the spinal cord leading to spastic paraplegia, adrenal insufficiency and in some cases testicular insufficiency.
Multislice proton MRSI may be a suitable technique for the prediction of lesion progression on MRI in X-linkedadrenoleukodystrophy.
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So far PGD has been carried out for three carrier females at risk of transmitting X-linkedadrenoleukodystrophy, X-linked hydrocephalus and hemophilia A.
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Magnetic resonance imaging sequences such as diffusion and spectroscopy have been well studied in X-linkedadrenoleukodystrophy, but no data exist on magnetic resonance perfusion imaging.
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X-linkedadrenoleukodystrophy is a neurodegenerative disorder affecting the myelin of the nervous system and the adrenal cortex.