Somatostatin analogs are an alternative treatment to pituitary surgery and radiotherapy in acromegalic patients.
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Patients Nineteen acromegalic patients with active disease after unsuccessful neurosurgery and somatostatin analog therapy.
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Our findings suggest that both insulin sensitivity and β-cell function are improved by tumor resection in acromegalic patients.
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In conclusion, this study demonstrates the key role of RUNX2 gene overexpression in causing bone impairment in acromegalic patients.
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This study aims to determine whether the detection of this mutation could impact on the management of acromegalic patients.
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Mortality analysis has shown as many as 60 % of acromegalic patients die due to cardiovascular disease.
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We aimed to elucidate the skeletal conditions of acromegalic patients by means of bone microarchitecture analysis and evaluation of MSCs osteogenic commitment.
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Material and methods: We selected 68 consecutive acromegalic patients referred to our hospital during a 5-yr period.
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Our results showed an abnormal microarchitecture and demonstrated that bone impairment in acromegalic patients is associated with the upregulation of RUNX2 expression.
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This study aimed to evaluate dQT as an early predictor of ventricular tachyarrhythmia, as sudden cardiac death commonly occurs in acromegalic patients.
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The aim of this study was to establish the existence of primary acromegalic cardiomyopathy different from the cardiovascular complications often associated with acromegaly.
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Ingestion of glucose is known to induce suppression of GH secretion in normal subjects and this phenomenon is often absent in acromegalic patients.
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Thirty-four acromegalic patients, referred to our non-invasive laboratory and divided into two groups on the basis of the presence of hypertension, underwent echocardiographic studies.
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We think that a non-invasive, simple and inexpensive marker-measurement of dQT-as part of cardiac monitoring could be valuable for screening complications in acromegalic patients.
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Results: In the study population, 21% of the 2392 acromegalic patients initially followed in 25 tertiary endocrinology centres were lost to follow-up.
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Methods: Acromegalic patients were considered lost to follow-up if no new information had been entered in their hospital records during the previous 2 years.