Significados de allelic imbalance en inglés

We identified nine loci which show evidence of preferential allelic imbalance.

Investigation of allelic imbalance using microsatellite markers located near the E-cadherin locus was also performed.

The method is based on pattern recognition of segmented and smoothed copy number and allelic imbalance profiles.

Quantitative analysis of the C2 domain sequences revealed that A:G allelic imbalance was strongly linked to esophageal malignancy.

We also found SNVs for which we can anticipate allelic imbalance from the disruption of a binding motif.

Array comparative genomic hybridisation indicated that this nonrandom allelic imbalance was due to amplification of the rare allele.

Of the 48 samples, 32 showed statistically significant allelic imbalance.

We analyzed 31 such lymphomas using 73 microsatellite markers for allelic imbalance and microsatellite instability.

These results suggest that at least three different regions are involved in allelic imbalance on chromosome arm 16q in breast cancer.

Conclusions: We demonstrate that allelic imbalance can be used to determine an inactivation status for X-linked genes, even without completely non-random XCI.

RNA-seq data collected from F1 reciprocal crosses in mice can powerfully dissect strain and parent-of-origin effects on allelic imbalance of gene expression.

However, all tumors showed only partial loss of allele signal intensities, and it was not clear whether this represented allelic imbalance or cellular heterogeneity.

However, in many cases the resulting allelic imbalance relative to normal DNA was weak, suggesting that only part of the tumor showed this abnormality.

These data suggest that allelic imbalance of chromosome 5 is involved in at least a subset of neuroblastomas and influences survival in patients with neuroblastoma.

These 6q aberrations were found to be the sole allelic imbalance in 1 patient only; they were mostly accompanied by additional abnormalities.

Allelic imbalances have been used genome-wide to detect mono-allelically expressed genes.