A Weibull survival model was used in order to predict individual ANM.
2
Wider implications of the findings: Age-specific AMH levels are predictive for ANM.
3
In the candidate gene association studies on ANM, very few consistent associations were found.
4
Age at natural menopause (ANM) is largely influenced by genetic factors.
5
The dam holds 6 million cubic meters of mining waste, according to mining regulator ANM.
6
What is known already: A fixed interval is hypothesized to exist between ANM and age at loss of natural fertility.
7
In conclusion, AMH and mother's ANM both have added value in forecasting TTM for the daughter based on her age.
8
Wider implications of the findings: This study shows that AMH is a more accurate predictor of ANM than mother's ANM.
9
CONCLUSION A number of genetic variants have been discovered in association with ANM, although the overall results have been rather disappointing.
10
We identified one trans-ethnic array-wide SNP association with AAM and two significant associations with ANM, which have not been described previously.
11
What is known already: Mother's ANM is considered a proxy for daughter's ANM although studies on its predictive accuracy are non-existent.
12
Therefore, if it is possible to predict ANM, one could identify women destined for early menopause and thus at higher risk for age-related subfertility.
13
METHODS The electronic databases of Pubmed and Embase were systematically searched until September 2009 for genetic studies on ANM, using relevant keywords on the subject.
14
Cox proportional hazards analysis estimated uni- and multivariate regression coefficients for female age at study entry, mother's ANM and AMH in the prediction of TTM.
15
The mean weighted NRI suggests that a 47% improvement in predictive accuracy is offered by adding AMH to the model of age and mother's ANM.
16
We report a dual strategy in -70,000women to identify common and low-frequencyprotein-codingvariation associated with age at natural menopause (ANM).