Enfortumab vedotin is a new type of treatment called an antibody-drugconjugate.
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Background: Glembatumumab vedotin is an antibody-drugconjugate that produced preliminary clinical activity against advanced melanoma in a phase 1 dose-escalation trial.
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Also monoclonal antibody as a carrier of anticancer drug was mentioned and its problems was discussed from the aspect of pharmacokinetics of antibody-drugconjugate.
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Antibody-drugconjugates (ADCs) have achieved great success in cancer therapy in recent years.
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Antibody-DrugConjugates (ADC)s-based therapy has been proposed as potential strategy to treat this pediatric malignancy.
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In order to ameliorate survival rates of patients, new therapeutic approaches have been evaluated, mainly immunotherapy with antibody-drugconjugates or immunoconjugates.
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FRANKFURT (Reuters) - A class of treatments known as antibody-drugconjugates (ADC) combine cancer-tracking proteins with powerful cell toxins.
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Antibody-drugconjugates are targeted anticancer agents consisting of a cytotoxic drug covalently linked to a monoclonal antibody for tumor antigen-specific activity.
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Antibody-drugconjugates (ADC) are used to selectively deliver cytotoxic agents to tumors and have the potential for increased clinical benefit to cancer patients.