1
However, three-quarters of GPs were unfamiliar with the details of DNA based linkage analysis.
2
Variant- based two-point linkage analysis and gene- based linkage analysis was performed.
3
Using data from the Netherlands Twin Register, a sib-pair- based linkage analysis for adult height was conducted.
4
We validate these results experimentally by implementing the sequence- based linkage approach for chromosome 19 in CEPH pedigrees.
5
Initial localization of disease-related loci has traditionally been performed using family- based linkage methods to scan the genome.
6
Multipoint model- based linkage analysis was carried out under a dominant mode of inheritance for the disease using the 'affected only' approach.
7
Considering that few large family- based linkage studies have as yet been performed on haemostasis and inflammation-related traits, additional studies are highly needed.
8
Background: Several chromosomal regions have been identified using family- based linkage analysis to contain genes contributing to the development of asthma and allergic disorders.
9
Analysis of the patterns of segmental sharing has the potential to map disease loci that contain multiple rare variants in a population- based linkage analysis.
10
We conclude that covariate- based linkage analysis greatly improves the likelihood that linked regions will be found by incorporation of information about heterogeneity within the sample.
11
Initial indications are that these studies are capable of discovering loci associated with relative risks too modest to have been detectable through family- based linkage studies.
12
The second objective was to employ RB1 molecular deletion and microsatellite- based linkage analysis as laboratory tools, while counseling families with a history of retinoblastoma (RB).