Significados de bipolar spindle en inglés

We show that Asp1 kinase function is required for bipolar spindle formation.

Proper centrosome separation is a prerequisite for positioning the bipolar spindle.

This inhibition of bipolar spindle formation correlates with an accumulation of cells in prometaphase.

This ensures rMT dissolution and bipolar spindle formation.

Finally, the ability of FTI-2153 to inhibit tumor cell proliferation does not correlate with inhibition of bipolar spindle formation.

The number of centrioles is tightly controlled to ensure bipolar spindle assembly, which is a prerequisite to maintain genome integrity.

The rMT is then dissolved upon the onset of meiosis I when a bipolar spindle emerges to conduct chromosome segregation.

However, Eg5-independent pathways for bipolar spindle formation exist, which might promote resistance to treatment with Eg5 inhibitors.

PMID: 29898389 The number of centrioles is tightly controlled to ensure bipolar spindle assembly, which is a prerequisite to maintain genome integrity.

Inhibitors of different chemical classes have been identified that target human Eg5, a kinesin responsible for the establishment of the bipolar spindle.

Thus, a mechanism by which FTIs inhibit progression through mitosis and tumor growth is by blocking bipolar spindle formation and chromosome alignment.

STARD9 is a largely uncharacterized mitotic kinesin and putative cancer target that is critical for regulating pericentriolar material cohesion during bipolar spindle assembly.

This represents the first identification of a prokaryotic tubulin with the dynamic instability of microtubules and the ability to form a simplified bipolar spindle.

As a bipolar spindle is formed, the median MT length increases to approximately 300 nm and then decreases to approximately 30 nm in late anaphase.

Cells normally containing centrosomes are still able to build bipolar spindles after their centrioles have been removed or ablated.

FTI-2153 inhibited the ability of A-549 and Calu-1 cells to form bipolar spindles and caused formation of monoasteral spindles.