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We demonstrate that both pain and markers of ER stress are reversed by a chemicalchaperone.
2
We aimed at identifying mutants with preserved transport activity but with improper plasma membrane localization for rescue by the chemicalchaperone 4-phenylbutyrate (4-PBA).
3
Chemicalchaperone therapy and gene therapy hold promise for the future.
4
Chemical inducers of ER stress invariably lead to pain behavior that is reversed by a chemicalchaperone and an inhibitor of sEH.