Significados de chimeric receptor en inglés

Sulfation of N-terminal tyrosines contributed to the function of this chimeric receptor.

The slow degradation of EGFR-AMSH resulted in the sustained signaling activity of this chimeric receptor.

Furthermore, target cell death correlated with the level of chimeric receptor expression on the effector MD45 subclones.

In summary, we have developed a highly efficient gene transfer system for evaluating chimeric receptor expression in cytotoxic lymphocytes.

In contrast, neither human CSF-1R nor the chimeric receptor was able to function in interleukin-2-dependent murine T cells.

We generated dual-specific T cells by genetic modification of alloreactive T cells with a chimeric receptor recognizing folate-binding protein, an ovarian cancer-associated antigen.

To extend this approach to colon cancer we report here redirection of T cells using a chimeric receptor recognizing the colon cancer-associated Ag EGP40.

Conclusions: We have shown that chimeric receptor tyrosine kinases escape ubiquitination and down-regulation and that their stabilization is critical to efficient stimulation of cell proliferation.

However, a chimeric receptor in which the DD of CD120a was fused to the cytoplasmic domain of CD120b was predominantly localized to lipid rafts.

Both chimeric receptors still could bind insulin with as high affinity as the wild-type receptor.

In addition, none of the individual mutations alone could account for the changes exhibited by the chimeric receptors.

Activation of Stat5 and hemoglobin expression by EGF were markedly impaired in cells expressing the tyrosine mutated chimeric receptors.

In addition, chimeric receptors containing exon 3 of the IGF-IR could also bind with high affinity both IGF-I and IGF-II.

Chimeric receptors have been constructed that further support these conclusions and indicate that at least two hETA regions contribute to ligand selectivity.

Chimeric receptors carrying the extracellular domain of the EGF receptor and the intracellular domain of the EPOR were introduced into SKT6 cells.

Soluble chimeric receptors, tyrosine kinase inhibitors, and monoclonal antibodies against VEGF and molecular targets in the integrin and Delta-like protein 4-Notch pathways are being developed.