However, implication of LXRs in the selective uptake of cholesterylesters from lipoproteins in human macrophages has never been reported.
2
A simple method has been developed for labelling human plasma lipoproteins to high specific radioactivity with radioactive cholesterylesters in vitro.
3
They serve to transport endogenously synthesized lipids, mainly triglycerides (but also some cholesterol and cholesterylesters) to peripheral tissues.
4
Lysosomal acid lipase (LAL) is a key enzyme that cleaves cholesterylesters and triglycerides to generate free fatty acids and cholesterol in lysosomes.
5
Inhibition of ACAT, the enzyme which catalyses the intracellular formation of cholesterylesters, is a very attractive target for the treatment of hypercholesterolaemia and atherosclerosis.
6
Lysosomal acid lipase (LAL) is essential for the hydrolysis of cholesterylesters and triglycerides to generate cholesterol and free fatty acids in cellular lysosomes.
7
Insulin also increased the percentage of palmitoleic acid (16:1) and decreased the percentages of saturated fatty acids and n-6 fatty acids in aortic cholesterylesters.