Prestimulation of tissues with forskolin significantly affected activation kinetics and binding characteristics.
2
Concentration-response curves for isoprenaline and forskolin were generated in the cerebral cortex.
3
THC was also able to antagonize the forskolin-induced elevation of intracellular cAMP concentration.
4
The effect of forskolin on cGMP regulation was investigated using dispersed rat pinealocytes.
5
Similar structure-dependent inhibitory effects were observed in forskolin-stimulated rat colonic epithelium.
1
Epinephrine and colforsin produced concentration-dependent increases in cAMP production.
2
When barium was substituted for Ca in the extracellular fluid, the cAMP response to colforsin was restored, despite Bay K 8644.
3
Inhibition of Ca channel permeability with cadmium or cobalt ions partially restored colforsin-stimulated cAMP production, despite the presence of extracellular Ca and Bay K 8644.
4
The cAMP production was measured by radioimmunoassay under control conditions and after incubation with epinephrine or colforsin (forskolin) in the presence and absence of inhibitors.
5
The calcium channel agonist Bay K 8644 (50 microM) combined with normal extracellular Ca concentration significantly attenuated colforsin-induced increases in cAMP production.